Phosphotidyl serine IgG antibody - Serum

Phosphatidylserine IgG Antibody – Serum Test

The Phosphatidylserine IgG Antibody – Serum Test is a laboratory blood test that detects IgG autoantibodies against phosphatidylserine, a phospholipid component of cell membranes. These antibodies belong to the broader group of antiphospholipid antibodies (aPL) and may be present in individuals with antiphospholipid syndrome (APS) or certain autoimmune disorders.

Antiphospholipid syndrome is an autoimmune condition in which the immune system produces antibodies that increase the risk of abnormal blood clot formation (thrombosis) and pregnancy-related complications. APS may occur as a primary disorder or in association with autoimmune diseases such as systemic lupus erythematosus (SLE).

Patients with APS may experience:

• Deep vein thrombosis (DVT)
• Pulmonary embolism
• Stroke or transient ischemic attack (TIA)
• Recurrent miscarriages
• Stillbirth
• Pre-eclampsia
• Placental insufficiency
• Low platelet count (thrombocytopenia)

The Phosphatidylserine IgG Antibody Test may be requested as part of an extended antiphospholipid antibody evaluation, especially when patients have clinical features suggestive of APS but standard antiphospholipid antibody tests are negative or inconclusive.

A positive Phosphatidylserine IgG result suggests the presence of autoantibodies directed against phosphatidylserine. However, the presence of these antibodies alone does not establish the diagnosis of antiphospholipid syndrome. Results must be interpreted together with clinical history, thrombotic events, pregnancy outcomes, and other laboratory findings.

The internationally accepted laboratory criteria for diagnosing APS currently include:

• Lupus Anticoagulant (LA)
• Anticardiolipin (aCL) IgG and IgM
• Anti-β2 Glycoprotein I (anti-β2GPI) IgG and IgM

Phosphatidylserine antibodies are considered non-criteria antiphospholipid antibodies. They may provide additional diagnostic information in selected patients but are not included in the revised Sydney classification criteria for APS.

Benefits of the Test

• Detects Phosphatidylserine IgG autoantibodies.
• Supports evaluation of suspected antiphospholipid syndrome.
• Assists in investigating unexplained thrombosis.
• Helps evaluate recurrent pregnancy loss.
• Complements standard antiphospholipid antibody testing.
• Requires only a simple blood sample.
• Supports autoimmune disease evaluation.
• Assists specialist clinical decision-making.

Why Doctors Recommend This Test

Doctors may recommend the Phosphatidylserine IgG Antibody Test for patients with:

• Recurrent unexplained blood clots.
• Recurrent miscarriages.
• Suspected antiphospholipid syndrome.
• Systemic lupus erythematosus.
• Autoimmune disorders with thrombotic complications.
• Unexplained pregnancy complications.

Preparation Before the Test

No special preparation is required.

You may eat and drink normally unless instructed otherwise. Inform your healthcare provider about previous blood clots, pregnancy history, autoimmune diseases, anticoagulant therapy, and recent infections. A blood sample is collected from a vein for laboratory analysis.

Normal Reporting Time

Typically: 3–7 Working Days

Reporting time may vary depending on the laboratory methodology.

Who Should Take This Test?

This test may be recommended for:

• Patients with suspected antiphospholipid syndrome.
• Individuals with unexplained venous or arterial thrombosis.
• Women with recurrent pregnancy loss.
• Patients with systemic lupus erythematosus.
• Individuals with unexplained stroke at a young age.
• Patients with thrombocytopenia.
• Individuals undergoing autoimmune disease evaluation.
• Patients with non-criteria APS suspicion.
• Individuals referred by rheumatologists or hematologists.
• Anyone advised by their healthcare provider.