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Nuclear Medicine

Parathyroid in Hyderabad: Sestamibi Scan Explained

By Focus Diagnostics

9 October 2026

10 min read

Parathyroid Scan in Hyderabad: Sestamibi Scan Explained

A parathyroid scan is a specialized nuclear medicine imaging examination used to help identify and localize abnormal parathyroid tissue.

One of the commonly used techniques is a parathyroid sestamibi scan, which uses a radiotracer called technetium-99m sestamibi and a gamma camera to identify areas showing increased tracer retention.

Parathyroid imaging may be recommended when blood tests indicate abnormal parathyroid hormone or calcium levels and the doctor needs imaging information to help locate abnormal parathyroid tissue.

A parathyroid scan in Hyderabad can provide useful localization information, particularly when surgery is being considered for a patient with a confirmed parathyroid disorder.

What Are the Parathyroid Glands?

The parathyroid glands are small endocrine glands located near the thyroid gland in the neck.

Most people have four parathyroid glands, although their number and exact location can vary.

These glands produce parathyroid hormone (PTH), which plays an important role in regulating calcium levels in the body.

Abnormal activity of one or more parathyroid glands can lead to changes in calcium and PTH levels.

What Is a Parathyroid Sestamibi Scan?

A sestamibi scan is a nuclear medicine examination that uses a small amount of technetium-99m sestamibi radiotracer.

After the tracer is administered, it is distributed through the body. Abnormal parathyroid tissue may retain the tracer differently from surrounding tissues.

A gamma camera detects the radiation emitted by the tracer and creates images of the neck and upper chest region.

The images can help doctors identify a focus that may represent abnormal parathyroid tissue.

Why Is a Parathyroid Scan Done?

A parathyroid scan may be recommended when a doctor needs to localize abnormal parathyroid tissue.

It may be considered in selected patients with:

  • Elevated parathyroid hormone levels
  • Abnormal calcium levels
  • Suspected primary hyperparathyroidism
  • Confirmed parathyroid disease when localization is required
  • A suspected parathyroid adenoma
  • Previous parathyroid surgery with persistent or recurrent disease

The scan is generally used for localization, rather than as the only test used to diagnose a parathyroid disorder.

Blood tests and clinical evaluation remain important.

What Is Hyperparathyroidism?

Hyperparathyroidism occurs when the parathyroid glands produce an excessive amount of parathyroid hormone.

PTH helps regulate calcium and phosphate levels in the body. Abnormal PTH production can lead to changes in blood calcium levels and, in some patients, symptoms or complications.

Doctors may evaluate hyperparathyroidism using blood tests such as calcium and PTH measurements.

If abnormal parathyroid tissue is confirmed and localization is required, imaging such as a sestamibi scan may be considered.

What Is a Parathyroid Adenoma?

A parathyroid adenoma is a usually benign growth involving a parathyroid gland.

It can cause excessive production of parathyroid hormone in some patients and may be associated with primary hyperparathyroidism.

A sestamibi scan may help localize an abnormal parathyroid gland when the clinical and laboratory findings indicate that localization is needed.

However, imaging findings should always be interpreted together with blood test results and other clinical information.

How Does a Sestamibi Scan Work?

The examination generally involves administration of a small amount of technetium-99m sestamibi.

The radiotracer travels through the bloodstream and is taken up by tissues.

Images are acquired using a gamma camera at appropriate time points.

Abnormal parathyroid tissue may show different tracer retention compared with surrounding thyroid tissue.

The images are processed and interpreted to determine whether there is a focus that could represent abnormal parathyroid tissue.

What Happens During a Parathyroid Scan?

A typical parathyroid sestamibi scan may involve the following steps:

1. Medical Assessment

The nuclear medicine team reviews the doctor's prescription and relevant medical information.

Recent calcium, PTH and thyroid-related investigations may be relevant to the clinical assessment.

2. Radiotracer Administration

A small amount of technetium-99m sestamibi is administered, usually through an intravenous injection.

3. Initial Imaging

Images of the neck and upper chest are acquired using a gamma camera.

4. Delayed Imaging

Additional images may be obtained after an interval to assess how the tracer is retained or cleared from the thyroid and surrounding tissues.

5. Image Processing

The images are processed and reviewed by the appropriate medical professional.

Additional imaging such as SPECT or SPECT CT may be performed when required by the clinical protocol.

What Is SPECT CT in Parathyroid Imaging?

SPECT CT combines nuclear medicine SPECT imaging with CT anatomical imaging.

The SPECT component provides information about radiotracer distribution, while CT provides anatomical localization.

When used for parathyroid imaging, SPECT CT can help identify the anatomical location of a focus of abnormal tracer uptake.

This may be particularly useful when the abnormal tissue is small, located in an unusual position or difficult to localize on planar images.

What Does a Positive Sestamibi Scan Mean?

A positive or abnormal sestamibi finding generally means that an area shows tracer uptake or retention that may be compatible with abnormal parathyroid tissue.

However, a scan finding alone does not establish the diagnosis.

The result should be interpreted alongside:

  • PTH levels
  • Serum calcium
  • Other laboratory findings
  • Symptoms
  • Previous imaging
  • Clinical history

The treating doctor determines the significance of the imaging findings.

Can a Parathyroid Scan Detect a Parathyroid Adenoma?

A sestamibi scan can help localize a parathyroid adenoma in appropriate patients.

The scan is particularly useful when the doctor has already established or strongly suspects a parathyroid disorder and needs anatomical localization.

Not every abnormal parathyroid gland will show the same imaging appearance, so results should be interpreted by the appropriate medical professional.

Can a Parathyroid Scan Find Ectopic Parathyroid Tissue?

Parathyroid tissue can occasionally be located outside its usual position.

Depending on the location and the imaging protocol, sestamibi imaging with SPECT CT may help localize ectopic parathyroid tissue.

The exact imaging approach depends on the clinical situation.

How Should You Prepare for a Parathyroid Scan?

Preparation requirements can vary depending on the imaging protocol and the centre.

Patients should:

  • Follow the instructions provided by the nuclear medicine team
  • Bring relevant blood test and previous imaging reports if available
  • Inform the team about current medications
  • Inform the team about previous thyroid or parathyroid surgery
  • Inform the team about pregnancy or possible pregnancy
  • Inform the team if breastfeeding

Do not stop prescribed medication unless specifically instructed by your doctor or nuclear medicine team.

Is a Sestamibi Scan Painful?

The imaging itself is generally painless.

The radiotracer is usually administered through an intravenous injection, which may cause brief discomfort at the injection site.

During imaging, the patient generally needs to remain still to obtain clear images.

Is a Parathyroid Sestamibi Scan Safe?

A sestamibi scan involves exposure to a small amount of radiation from the radiotracer.

The amount administered is selected according to the examination protocol and clinical requirement.

Patients should inform the medical team if they are pregnant, may be pregnant or are breastfeeding.

The healthcare team can provide specific guidance based on the examination.

How Long Does a Parathyroid Scan Take?

A parathyroid sestamibi scan may involve imaging at more than one time point.

The total appointment time therefore depends on the radiotracer protocol, image acquisition and whether additional SPECT or SPECT CT imaging is required.

Patients should allow sufficient time for the complete examination.

The diagnostic centre can provide an approximate schedule when the scan is booked.

What Happens After a Parathyroid Scan?

Most patients can return to their normal activities after the scan unless specific instructions are provided.

Patients may be advised to drink fluids to support normal elimination of the radiotracer.

The images are processed and interpreted by the appropriate medical professional, and the report is provided to the referring doctor.

Parathyroid Scan vs Thyroid Ultrasound

A thyroid ultrasound and parathyroid sestamibi scan provide different information.

Ultrasound provides detailed anatomical information about the thyroid and surrounding neck structures.

Sestamibi imaging provides functional nuclear medicine information based on radiotracer uptake and retention.

In selected patients, both examinations may be used together to improve localization.

Parathyroid Scan vs Blood Tests

Blood tests such as calcium and PTH are important for evaluating parathyroid function.

A sestamibi scan does not replace these laboratory tests.

Instead, the scan is generally used to provide localization information when a parathyroid abnormality has already been identified or strongly suspected.

Parathyroid Scan Cost in Hyderabad

The cost of a parathyroid sestamibi scan in Hyderabad can vary depending on the radiotracer, imaging protocol and whether additional SPECT or SPECT CT imaging is required.

For accurate pricing, patients should provide the exact examination name mentioned on their doctor's prescription when contacting the diagnostic centre.

Parathyroid Scan in Hyderabad

Patients searching for a parathyroid scan in Hyderabad can contact Focus Diagnostics to enquire about the examination, preparation requirements, availability and appointment details.

It is useful to provide the doctor's prescription and relevant blood test reports when scheduling the examination.

Why Choose Focus Diagnostics?

Focus Diagnostics provides diagnostic imaging and laboratory services for patients in Hyderabad.

If your doctor has recommended a parathyroid sestamibi scan, you can contact Focus Diagnostics to enquire about the required examination, preparation requirements and availability.

The appropriate imaging examination should be selected according to your doctor's clinical recommendation.

When Might a Doctor Recommend a Sestamibi Scan?

A doctor may recommend a sestamibi scan when laboratory tests and clinical findings suggest a parathyroid disorder and localization of abnormal tissue is required.

It may be considered particularly when:

  • PTH levels are elevated
  • Calcium levels are abnormal
  • Hyperparathyroidism has been diagnosed
  • A parathyroid adenoma is suspected
  • Surgery is being considered
  • Persistent or recurrent disease is suspected after previous surgery

The scan is generally part of a broader diagnostic and treatment-planning process.

Book a Parathyroid Sestamibi Scan in Hyderabad

If you have been advised to undergo a parathyroid scan, contact Focus Diagnostics with your doctor's prescription or referral.

The diagnostic team can provide information about the examination, preparation, availability and appointment requirements.

For appointments and enquiries: 91213 77123

Conclusion

A parathyroid sestamibi scan is a nuclear medicine imaging examination used to help localize abnormal parathyroid tissue.

It can be useful when a parathyroid disorder has been identified or is strongly suspected and the doctor needs additional localization information for treatment planning.

The scan uses a small amount of technetium-99m sestamibi and a gamma camera. SPECT CT may also be used when more precise anatomical localization is required.

If you are looking for a parathyroid scan in Hyderabad, consult your doctor and contact the diagnostic centre with your prescription and relevant reports to confirm the appropriate examination and preparation requirements.

Frequently Asked Questions

What is a parathyroid sestamibi scan?

A parathyroid sestamibi scan is a nuclear medicine examination that uses technetium-99m sestamibi to help localize abnormal parathyroid tissue.

Why is a sestamibi scan done?

It is generally used to help locate abnormal parathyroid tissue when a parathyroid disorder has been confirmed or strongly suspected.

Can a sestamibi scan detect a parathyroid adenoma?

It can help localize a parathyroid adenoma in appropriate patients, but imaging findings need to be interpreted together with blood tests and clinical information.

Does a parathyroid scan diagnose hyperparathyroidism?

The diagnosis of hyperparathyroidism is primarily based on clinical assessment and laboratory findings such as calcium and PTH. A sestamibi scan is mainly used for localization.

What is SPECT CT parathyroid imaging?

SPECT CT combines functional information from nuclear medicine imaging with anatomical information from CT, which can help localize abnormal parathyroid tissue more precisely.

Is a parathyroid scan painful?

The imaging itself is generally painless. An intravenous injection used to administer the radiotracer may cause brief discomfort.

How long does a parathyroid sestamibi scan take?

The examination may require imaging at different time points. The total duration depends on the imaging protocol and whether additional SPECT or SPECT CT images are required.

Do I need to fast before a sestamibi scan?

Preparation can vary according to the examination protocol. Follow the instructions provided by the nuclear medicine team.

Is a sestamibi scan safe?

The scan involves a small amount of radiation from the radiotracer and is performed when clinically appropriate. Inform the medical team about pregnancy or breastfeeding.

Where can I get a parathyroid scan in Hyderabad?

You can contact Focus Diagnostics at 91213 77123 to enquire about parathyroid sestamibi scan availability, preparation requirements and appointments.

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DKReviewed by Dr. Koushik Aravapalli, MBBS, DMRD, DNB, EDIR, DICR

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