CHROMOSOMAL ANALYSIS -MICROARRAY (COUPLES)

The Chromosomal Analysis – Microarray (Couples) test is an advanced genetic investigation performed on both partners to identify chromosomal abnormalities, copy number variations (CNVs), microdeletions, and microduplications that may affect fertility, pregnancy outcomes, or the risk of passing genetic conditions to children.

Chromosomal Microarray Analysis (CMA) is a high-resolution genetic technology that examines the entire genome for gains and losses of chromosomal material that may not be detectable through conventional chromosome studies. This test provides valuable information for couples experiencing infertility, recurrent pregnancy loss, repeated IVF failure, stillbirth, or a family history of genetic disorders.

Unlike traditional karyotyping, microarray testing can identify very small chromosomal changes associated with developmental disorders, congenital abnormalities, and reproductive challenges. Evaluating both partners helps clinicians better understand potential genetic factors that may influence conception and pregnancy outcomes.

Benefits of the Test

• Detects submicroscopic chromosomal abnormalities
• Identifies genetic causes of reproductive difficulties
• Helps evaluate recurrent pregnancy loss
• Assists in infertility investigations
• Supports family planning decisions
• Provides information for genetic counseling
• Helps assess reproductive risks for future pregnancies

Why Doctors Recommend This Test

Doctors may recommend Chromosomal Microarray Analysis for couples in cases of:

• Recurrent miscarriages
• Infertility of unknown cause
• Repeated IVF or assisted reproduction failure
• Previous child with genetic abnormalities
• Family history of chromosomal disorders
• Unexplained fetal abnormalities
• Stillbirth or recurrent pregnancy complications
• Preconception genetic evaluation

The test helps identify chromosomal changes that may affect fertility, embryo development, and pregnancy success.

Preparation Before Test

The test typically requires a blood sample from both partners.

• No fasting is required
• No special preparation is usually necessary
• Inform your doctor about previous genetic testing
• Share relevant family and reproductive history

Genetic counseling may be recommended before and after testing to help understand the results.

Normal Reporting Time

Results are typically available within 2 to 4 weeks, depending on laboratory workflow and analysis complexity.

Who Should Take This Test?

• Couples experiencing recurrent miscarriages
• Individuals undergoing fertility evaluation
• Couples with repeated IVF failures
• Those with a family history of genetic disorders
• Couples planning pregnancy after previous genetic abnormalities
• Individuals referred for reproductive genetic counseling

Chromosomal Microarray Analysis provides valuable information that can help guide reproductive decisions, fertility treatments, and prenatal planning.

Clinical Significance

The test may help identify:

• Microdeletion syndromes
• Microduplication syndromes
• Copy number variations (CNVs)
• Chromosomal imbalances
• Genetic causes of recurrent pregnancy loss
• Genetic factors contributing to infertility
• Reproductive genetic risks
• Inherited chromosomal abnormalities affecting offspring

The results can assist fertility specialists, geneticists, and reproductive medicine experts in developing personalized management plans.