IMMUNOHISTOCHEMISTRY, CALRETININ

The IHC – Calretinin test is an immunohistochemistry-based diagnostic assay used to detect calretinin protein expression in tissue samples. Calretinin is a calcium-binding protein commonly expressed in mesothelial cells and certain neural tissues, making it an important marker in pathology for identifying mesothelioma and neural-origin tumors.

This test is widely used in oncology and surgical pathology to differentiate malignant mesothelioma from metastatic adenocarcinoma and to evaluate specific neural and soft tissue tumors. Calretinin staining helps pathologists accurately determine tumor origin and improve diagnostic precision.

Benefits of the Test

• Helps diagnose malignant mesothelioma
• Assists in differentiating mesothelioma from adenocarcinoma
• Supports identification of neural-origin tumors
• Improves tumor classification accuracy
• Helps guide oncology treatment planning

Why Doctors Recommend This Test

Doctors recommend the IHC Calretinin test when there is suspicion of mesothelial or neural tissue tumors. It is commonly used in:

• Diagnosis of malignant mesothelioma
• Evaluation of pleural and peritoneal tumors
• Differentiation of metastatic adenocarcinoma
• Neural tumor pathology studies
• Oncology biopsy interpretation

Calretinin is often used together with markers such as WT1, CK5/6, D2-40, BerEP4, and CEA to improve diagnostic accuracy in mesothelioma evaluation.

Preparation Before Test

No special preparation is required from the patient. Important points include:

• The test is performed on a biopsy or surgical tissue sample
• No fasting or medication restrictions are needed
• Clinical imaging and pathology history may assist interpretation

Normal Reporting Time

The typical turnaround time is 3 to 5 working days, depending on tissue processing and laboratory workflow.

Who Should Take This Test

• Patients with suspected mesothelioma
• Individuals with pleural or peritoneal tumors
• Cases requiring differentiation between mesothelioma and adenocarcinoma
• Patients with neural-origin tumor suspicion
• Oncology patients requiring immunohistochemistry profiling

The IHC Calretinin test is an important diagnostic tool in modern pathology and oncology. By detecting calretinin expression in tissue samples, it helps clinicians accurately identify mesothelial and neural-origin tumors, ensuring effective diagnosis and treatment planning.