HEREDITARY CANCER PANEL BY NGS

Hereditary Cancer Panel by NGS is an advanced genetic test that uses Next Generation Sequencing (NGS) technology to analyze multiple genes associated with inherited cancer syndromes. This comprehensive test helps identify genetic mutations that may increase an individual's lifetime risk of developing certain cancers.

Many cancers occur sporadically, but a significant percentage are linked to inherited genetic mutations passed down through families. Hereditary Cancer Panel testing evaluates cancer susceptibility genes such as BRCA1, BRCA2, TP53, MLH1, MSH2, MSH6, PMS2, APC, CHEK2, PALB2, and other clinically relevant genes associated with hereditary cancer syndromes.

Benefits of the Test

• Identifies inherited cancer risk genes.
• Supports early cancer detection strategies.
• Helps assess family cancer risk.
• Provides personalized risk assessment.
• Guides preventive healthcare decisions.
• Supports genetic counseling and family screening.
• Assists in personalized treatment planning.
• Uses highly accurate NGS technology.

Why Doctors Recommend This Test

Doctors recommend Hereditary Cancer Panel testing for individuals with a strong family history of cancer, early-onset cancers, multiple cancers within the family, known hereditary cancer syndromes, or individuals seeking genetic risk assessment for cancer prevention.

The test helps identify inherited genetic mutations that may increase susceptibility to breast cancer, ovarian cancer, colorectal cancer, prostate cancer, pancreatic cancer, and other hereditary malignancies.

Preparation Before Test

• No fasting is required.
• A blood sample is usually collected for testing.
• Genetic counseling may be recommended before testing.
• Provide detailed family medical history if available.
• Inform your doctor about previous genetic testing.
• Follow sample collection instructions provided by the laboratory.

Normal Reporting Time

Most Hereditary Cancer Panel by NGS reports at Focus Diagnostics are available within 2–3 weeks after sample collection. Reporting time may vary depending on the complexity of genetic analysis and variant interpretation.

Who Should Take This Test?

This test may be recommended for:

• Individuals with a family history of cancer.
• Patients diagnosed with cancer at a young age.
• People with multiple family members affected by cancer.
• Individuals with hereditary cancer syndrome suspicion.
• Patients seeking genetic cancer risk assessment.
• People considering preventive cancer screening.
• Individuals requiring personalized oncology care.
• Family members of mutation-positive patients.

Detailed Information

Hereditary cancers result from inherited genetic mutations that increase susceptibility to specific cancer types. Unlike sporadic cancers, hereditary cancers often occur at younger ages, affect multiple family members, and may involve multiple primary cancers in the same individual.

The Hereditary Cancer Panel by NGS uses advanced Next Generation Sequencing technology to simultaneously analyze multiple cancer-associated genes with high sensitivity and accuracy. This comprehensive approach allows detection of pathogenic variants, likely pathogenic variants, and clinically relevant genetic alterations associated with hereditary cancer syndromes.

Genes commonly included in hereditary cancer panels are associated with conditions such as Hereditary Breast and Ovarian Cancer Syndrome (HBOC), Lynch Syndrome, Familial Adenomatous Polyposis (FAP), Li-Fraumeni Syndrome, Cowden Syndrome, Peutz-Jeghers Syndrome, and other inherited cancer predisposition disorders.

Identifying a disease-causing mutation enables healthcare providers to implement personalized surveillance programs, preventive strategies, risk-reducing interventions, and family screening recommendations. Genetic information may also influence treatment decisions in patients already diagnosed with cancer.

The test provides valuable information not only for the individual being tested but also for biological relatives who may share inherited genetic risks. Appropriate genetic counseling helps patients understand the implications of test results and make informed healthcare decisions.

At Focus Diagnostics, Hereditary Cancer Panel by NGS testing is performed using advanced genomic sequencing platforms, validated bioinformatics pipelines, and expert variant interpretation to provide accurate, reliable, and clinically meaningful genetic insights.