CHROMOSOMAL MICROARRAY (750K)- POC

Chromosomal Microarray (750K) - POC is an advanced molecular genetic test designed to evaluate products of conception (POC) following miscarriage, stillbirth, or pregnancy loss. Using high-resolution chromosomal microarray technology with approximately 750,000 genomic markers, the test detects chromosomal abnormalities, copy number variations, aneuploidies, microdeletions, and microduplications that may contribute to pregnancy loss.

Chromosomal abnormalities are among the most common causes of miscarriage and early pregnancy loss. Identifying the underlying genetic cause can provide valuable information for patients and healthcare providers, assist in future pregnancy planning, and help guide reproductive counseling.

Benefits of the Test

• Identifies chromosomal causes of pregnancy loss.
• Provides high-resolution genome-wide analysis.
• Detects aneuploidies, deletions, and duplications.
• Helps evaluate recurrent miscarriage.
• Supports reproductive and genetic counseling.
• Provides more detailed information than conventional karyotyping.
• Assists future pregnancy planning.
• Offers accurate genomic assessment of products of conception.

Why Doctors Recommend This Test

Doctors recommend Chromosomal Microarray (750K) - POC for patients who have experienced miscarriage, recurrent pregnancy loss, stillbirth, fetal abnormalities, or unexplained pregnancy complications. The test helps determine whether chromosomal abnormalities contributed to the pregnancy loss and provides important information for future reproductive decision-making.

Genetic evaluation of products of conception can help reduce uncertainty and support personalized reproductive care.

Preparation Before Test

• No patient preparation is required.
• Products of conception (POC) tissue specimen is required for testing.
• Proper specimen collection and preservation are essential.
• Provide relevant pregnancy and medical history.
• Genetic counseling may be recommended.
• Ensure prompt transport of the specimen to the laboratory.

Normal Reporting Time

Most Chromosomal Microarray (750K) - POC reports at Focus Diagnostics are available within 2–3 hours for specimen processing and laboratory workflow initiation. Final genomic analysis, interpretation, and reporting generally require several working days due to the complexity of chromosomal data analysis.

Who Should Take This Test?

This test may be recommended for:

• Patients with miscarriage or pregnancy loss.
• Couples with recurrent pregnancy loss.
• Cases of unexplained fetal demise.
• Pregnancies with suspected chromosomal abnormalities.
• Patients requiring genetic evaluation of products of conception.
• Individuals seeking reproductive risk assessment.
• Couples undergoing fertility evaluation.
• Patients referred for genetic counseling.

Detailed Information

Pregnancy loss is a common reproductive event, and chromosomal abnormalities account for a significant proportion of miscarriages, particularly during the first trimester. Genetic abnormalities such as trisomies, monosomies, polyploidies, and structural chromosomal imbalances can interfere with normal fetal development and result in pregnancy failure.

Chromosomal Microarray (750K) - POC utilizes advanced genomic technology to examine the fetal genome at a much higher resolution than conventional chromosome analysis. The microarray platform contains approximately 750,000 probes distributed across the genome, allowing detection of copy number variations (CNVs), microdeletions, microduplications, and chromosomal imbalances that may not be visible through routine cytogenetic testing.

The test is performed on products of conception tissue obtained following miscarriage, fetal loss, or pregnancy termination. Unlike traditional karyotyping, chromosomal microarray analysis does not require viable cell culture, which significantly improves diagnostic yield and reduces the likelihood of inconclusive results due to culture failure.

Chromosomal abnormalities identified through microarray testing can help explain the cause of pregnancy loss, provide reassurance to affected families, and assist healthcare providers in determining recurrence risks. Results may also influence recommendations regarding future pregnancies, fertility treatments, and additional genetic investigations.

The test is particularly valuable for couples experiencing recurrent pregnancy loss, as identifying an underlying genetic cause can help guide further reproductive planning and counseling. In some cases, parental chromosomal studies may also be recommended depending on the findings.

Because genomic testing may identify complex or unexpected findings, interpretation is performed by experienced genetic specialists. Genetic counseling is often recommended to help families understand the results and their implications for future pregnancies.

At Focus Diagnostics, Chromosomal Microarray (750K) - POC testing is performed using advanced genomic microarray platforms, high-resolution molecular technologies, and stringent quality assurance protocols to provide accurate, reliable, and clinically meaningful reproductive genetic information.