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Medically Reviewed By

Dr. Srinivas

Consultant Pathologist

Pathology · Last reviewed: June 2026

Anti-Cardiolipin Antibody IgG blood test for diagnosing Antiphospholipid Syndrome (APS) and autoimmune clotting disorders at Focus Diagnostics

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ANTI CARDIOLIPIN AB IGG

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About this test

The Anti-Cardiolipin Antibody (IgG) Test is a specialized blood test that measures Immunoglobulin G (IgG) antibodies directed against cardiolipin, a phospholipid found in cell membranes. These antibodies are one of the primary laboratory markers used to diagnose Antiphospholipid Syndrome (APS), an autoimmune disorder characterized by an increased tendency to develop abnormal blood clots.

The Anti-Cardiolipin IgG Test is commonly used to investigate unexplained thrombosis, recurrent miscarriages, pregnancy complications, and autoimmune diseases such as Systemic Lupus Erythematosus (SLE). The presence of persistent Anti-Cardiolipin IgG antibodies may indicate a higher risk of arterial or venous blood clots and pregnancy-related complications. This test is often performed alongside Anti-Cardiolipin IgM, Anti-β2 Glycoprotein I antibodies, and Lupus Anticoagulant testing for a comprehensive APS evaluation.

Benefits of the Test

  • Helps diagnose Antiphospholipid Syndrome (APS).
  • Detects Anti-Cardiolipin IgG antibodies with high accuracy.
  • Assists in evaluating unexplained blood clotting disorders.
  • Supports investigation of recurrent miscarriages and pregnancy complications.
  • Helps assess autoimmune diseases associated with APS.
  • Guides treatment decisions and long-term monitoring.

Why Doctors Recommend This Test

Doctors may recommend the Anti-Cardiolipin IgG Test for individuals with symptoms or medical conditions suggestive of Antiphospholipid Syndrome, including:

  • Deep vein thrombosis (DVT)
  • Stroke or transient ischemic attack (TIA)
  • Pulmonary embolism
  • Recurrent miscarriages
  • Recurrent pregnancy loss or stillbirth
  • Unexplained blood clotting disorders
  • Positive autoimmune disease evaluation
  • Low platelet count (thrombocytopenia)

The test is frequently ordered with Anti-Cardiolipin IgM, Anti-β2 Glycoprotein I Antibodies, Lupus Anticoagulant, ANA Profile, and other autoimmune investigations.

Preparation Before Test

  • No fasting is required.
  • Continue routine medications unless advised otherwise by your physician.
  • Inform your healthcare provider about blood-thinning medications, autoimmune conditions, and recent infections.
  • A blood sample is collected for laboratory analysis.

Normal Reporting Time

Reporting Time: Usually 2–5 working days, depending on laboratory processing protocols.

Who Should Take This Test?

This test is recommended for:

  • Individuals with unexplained blood clots.
  • Women with recurrent miscarriages or pregnancy complications.
  • Patients with suspected Antiphospholipid Syndrome (APS).
  • Individuals with Systemic Lupus Erythematosus (SLE).
  • Patients with unexplained thrombosis or low platelet counts.
  • Individuals referred by rheumatologists, hematologists, or obstetricians.

Patient-Friendly Summary

The Anti-Cardiolipin Antibody (IgG) Test is a blood test that helps detect antibodies associated with Antiphospholipid Syndrome (APS), an autoimmune disorder that increases the risk of abnormal blood clot formation. APS can lead to deep vein thrombosis, stroke, pulmonary embolism, recurrent miscarriages, and pregnancy complications. The Anti-Cardiolipin IgG antibody is one of the key laboratory markers used to diagnose this condition. The test is commonly performed along with other antiphospholipid antibody tests to provide a complete assessment. It is a simple and safe blood test that requires no fasting and helps physicians diagnose and monitor autoimmune clotting disorders.

Test FAQs

What is the Anti-Cardiolipin IgG Test?

It is a blood test that detects IgG antibodies against cardiolipin to help diagnose Antiphospholipid Syndrome (APS).

Why is this test performed?

It helps investigate unexplained blood clots, recurrent miscarriages, and autoimmune clotting disorders.

Is fasting required before the test?

No. Fasting is generally not required.

What sample is required?

A blood sample is collected for laboratory analysis.

What conditions can this test help diagnose?

It helps diagnose Antiphospholipid Syndrome (APS) and evaluate autoimmune clotting disorders.

Is this test performed with other antiphospholipid antibody tests?

Yes. It is commonly ordered with Anti-Cardiolipin IgM, Anti-β2 Glycoprotein I antibodies, and Lupus Anticoagulant testing.

Can this test help investigate recurrent pregnancy loss?

Yes. Persistent Anti-Cardiolipin IgG antibodies are associated with recurrent miscarriages and pregnancy complications.

How long does it take to receive results?

Results are usually available within 2–5 working days.

Is the Anti-Cardiolipin IgG Test safe?

Yes. It is a routine and safe blood test.

What should I do if my result is positive?

Consult your physician or a rheumatologist/hematologist for further evaluation. Repeat testing after 12 weeks may be recommended to confirm persistent antibody positivity as part of the diagnosis of APS.

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